Chromosome tranlocations: Still more about oncogenes

Why should we still care about oncogenes?

Although oncogenes and their transformation mechanisms have been known for 30 years, we are just now using our understanding of protein function to abrogate the activity of these genes to block cancer growth. The advent of specific small-molecule inhibitors has been a tremendous step in the fight against cancer and their main targets are the cellular counterparts of viral oncogenes. The best-kn...

Still More about Subfitness

Several features of subfitness are analyzed. Isbell’s Spatiality Theorem leads to the concept of T1-spatiality which is compared with the TD-spatiality. Subfitness is put into relation with other weak separation axioms (and with the existence of nearness), both in spaces and locales, and seeming discrepancies are explained. A new characteristic of subfitness by means of codensity is presented.

The chromosome territory of human oncogenes.

The prevailing view of the chromosome of higher organisms is characterized by randomness. Genes are believed to be located at random and mutations and most structural rearrangements are likewise supposed to occur at random (1-4). During the last few years the molecular organization of the eukaryotic chromosome has been subject to intensive investigation but the evidence has been mainly on singl...

For Chávez, Still More Discontent

Venezuela’s Hugo Chávez, who enjoys more domestic power and higher international name recognition than any other president of a Latin American democracy, is now facing serious political troubles. Since mid-2007, the Chávez administration has been beset by street protests, electoral setbacks, and economic woes that amount to a second wave of discontent. The first wave, when critics passionately ...

more about radioactive pollution